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Computational Biologist II, Internal Medicine

University of Texas Southwestern Medical Center
parental leave, paid time off, paid holidays, tuition reimbursement
United States, Texas, Dallas
5323 Harry Hines Boulevard (Show on map)
Aug 05, 2025

WHY UT SOUTHWESTERN?
With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to U.S. News & World Report, we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you'll discover a culture of teamwork, professionalism, and a rewarding career!

JOB SUMMARY
Perform professional work in support of scientific research using technical knowledge of software, software development, networking, and/or hardware in a complex computing environment. Subject matter expert in multiple areas of computing technology, and specific knowledge of molecular biology and genetics. Work collaboratively with Principal Investigator ("PI") to determine the most suitable computational methods and tools to analyze large-scale biological data sets. Prepare reports for presentation or publication. Responsible for assisting PI in meeting the system needs for multiple research projects and/or labs.

Looking for a creative candidate with an interest in developing and applying genetic epidemiological and population-based methods to study how polygenic variation impacts human health and disease. Focus areas include identifying metabolomic, proteomic and other -omic biomarkers related to disease, evaluating polygenic predictors of disease risk or outcomes, and identifying opportunities to translate genetics into clinical practice. The lab's approaches typically include applying discovery-oriented and hypothesis-oriented methodologies in genotyped populations derived from epidemiological and clinically-derived data sets, as well as resources such as All of Us and the UK Biobank.

Responsibilities would include developing and validating phenotypes, performing genetic quality control on data sets, constructing polygenic predictors, and performing analyses using a range of genetic methods. Essential skills include an understanding of epidemiological/statistical methods and an ability to work with large high-dimensional data sets within linux and cloud-based analytical environments. A clinically-oriented or biological background with experience in genetic research is preferred. Excellent written and verbal communication skills are needed to assist with presenting data and manuscript development. Experience with statistical packages such as R as well as genetic programs such as PLINK.

BENEFITS
UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:



  • PPO medical plan, available day one at no cost for full-time employee-only coverage
  • 100% coverage for preventive healthcare-no copay
  • Paid Time Off, available day one
  • Retirement Programs through the Teacher Retirement System of Texas (TRS)
  • Paid Parental Leave Benefit
  • Wellness programs
  • Tuition Reimbursement
  • Public Service Loan Forgiveness (PSLF) Qualified Employer
  • Learn more about these and other UTSW employee benefits!


EXPERIENCE AND EDUCATION
Required



  • Education
    PhD in Computer Science or a related field of biological science, with thesis work in bioinformatics and computational biology or
    Master's Degree in Computer Science or a related field of biological science or
    Bachelor's Degree in Computer Science or a related field of biological science


  • Experience
    2 years of related research experience in bioinformatics and computational biology with Master's Degree or
    4 years of related research experience in bioinformatics and computational biology with Bachelor's Degree.


JOB DUTIES



  • Manage computer hardware and software programming and maintenance for one or more research laboratories. Ensure existing systems meet the continuing needs of the labs and/or recommend and test new systems as necessary.
  • Perform or direct others to perform complex data analysis related to specialized research methodologies and results. Manage assigned research projects with minimal input from PI.
  • Develop and/or modify software to support new and ongoing research projects.
  • Resolve hardware, software, and network issues in support of the lab.
  • Oversee the development and maintenance of complex databases to support new and ongoing research projects.
  • Prepare research reports for presentation, and assist with preparation of manuscripts for publication.
  • May specialize in bioinformatics, software development, network administration, or hardware/software maintenance.
  • Perform other duties as assigned.


SECURITY AND EEO STATEMENT
Security
This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information. To the extent this position requires the holder to research, work on, or have access to critical infrastructure as defined in Section 113.001(2) of the Texas Business and Commerce Code, the ability to maintain the security or integrity of the critical infrastructure is a minimum qualification to be hired and to continue to be employed in the position.

EEO Statement
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.

Benefits
    UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:
    • PPO medical plan, available day one at no cost for full-time employee-only coverage
    • 100% coverage for preventive healthcare - no copay
    • Paid Time Off, available day one
    • Retirement Programs through the Teacher Retirement System of Texas (TRS)
    • Paid Parental Leave Benefit
    • Wellness programs
    • Tuition Reimbursement
    • Public Service Loan Forgiveness (PSLF) Qualified Employer
    • Learn more about these and other UTSW employee benefits!
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