Global Medical Director, Povetacicept

Job Description

General Summary:

The Global Medical Affairs Strategy Medical Director will provide medical leadership for the Povetacicept programs. Povetacicept (pove) is an enhanced, dual BAFF/APRIL inhibitor in pivotal development for the treatment of IgA Nephropathy (IgAN), primary Membranous Nephropathy (pMN), and generalized Myasthenia Gravis (gMG) that has best-in-class and pipeline-in-a-product potential across a variety of autoimmune diseases.

This role will be responsible for developing the medical strategy and medical plan under the direction of the Global Medical Affairs Lead/Executive Director, as well as executing against the medical plan encompassing the pove programs, with a focus on gMG. This role will collaborate closely with cross-functional groups to ensure that scientific and medical strategies are aligned with broader corporate and key stakeholder needs, as well as ensuring the voice of the patient and medical community is integrated into product strategies.

Key Duties and Responsibilities:

• Main focus will be on gMG Medical Affairs activities, but may contribute to activities for the kidney indications for pove (i.e., IgAN and pMN), as needed.
• Develops medical affairs plans, including Launch and Life Cycle Management plans
• Critically interprets scientific data, determines the potential impact of new research on clinical practice, and uses scientific and clinical data to formulate frameworks and disease management approaches
• Provides input from medical community into clinical development and commercial strategies
• Effectively communicates scientific data through presentations and publications
• Ensures country/regional insights and needs are considered in global medical strategies and activities
• Provides scientific input and expertise as a medical reviewer and supports the development of global medical, commercial, regulatory, and reimbursement documents
• Performs/oversees medical/scientific training for Medical, Commercial, and other internal stakeholders
• Reviews investigator-sponsored study (ISS) proposals and other research grants

Knowledge and Skills:

• Deep understanding of global medical, regulatory and commercial (including payer) environments
• Excellent understanding of government and industry guidelines, regulations, laws, etc., for appropriate scientific/medical exchange and communication with key external stakeholders (e.g., healthcare providers, payers, advocacy bodies)
• Deep understanding of market access in key countries
• Excellent written and oral communication skills to influence others internally/externally
• Ability to develop relationships in a highly matrixed environment, as well as external relationships with global, regional and local thought leaders and industry experts
• Ability to engage in positive dialogue and resolve conflicts in a constructive manner

Education and Experience:

• M.D. degree or equivalent (e.g., MBBS, D.O.)
• Strong immunology and/or neurology background preferred, as role will focus on gMG
• Requires at least 3 years of experience working in the biotech/pharma industry or the equivalent combination of education and experience. Experience working on asset(s) in highly competitive disease area(s) is a plus.
• Requires experience in a Medical Affairs function and in the analysis of research (pre-clinical or clinical) data and publications; working knowledge of biostatistics as well as scientific and clinical research methods, and clinical study design.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com