Research Scientist/Sr. Research Scientist, Purification Process Sciences

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)
The Senior Purification Scientist supports protein purification process development and optimization primarily for novel therapeutic monoclonal antibody products including bispecifics throughout all stages of clinical trials.

Essential Functions of the Job (Key responsibilities)

• Participate and present updates in routine group meetings.
• Write routine electronic laboratory notebook and development reports.
• Manage laboratory supplies and instrument maintenance.
• Prepare buffers and solutions needed for laboratory work.
• Conduct purification process development, optimization, and pilot scale-up manufacturing. Conduct routine analyses of in-process samples using relevant product purity and process impurity analytical tools.
• Conduct high-throughput protein purification to support cell line development.
• Conduct routine protein purification to support discovery team's material needs and cell culture development.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Degree (such as BS or MS) in biochemistry, bioengineering, biology, chemistry or related discipline, or equivalent relevant industry experience.
• Solid knowledge in protein chemistry and bioprocessing.
• Solid knowledge and hands-on experiences in various types of column/membrane chromatography (affinity, size exclusion, ion exchanges, HIC, multi-mode) and filtration technology (TFF and nanofiltration) for cell culture clarification, protein purification and analysis.
• Experience in protein purification process development and scale-upExperiences in using AKTA line of purification instruments from lab scale to pilot scale.
• Experience using UF/DF instrument for buffer exchange, product concentration, and formulation.
• Experience using depth filtration for cell culture clarificationExperiences in using analytical instruments for protein analysis such as HPLC, SoloVPE, SDS-PAGE or SDS-CGE, ELISA, etc.
• Strong written and verbal communication skills.
• Organized, collaborative, self-starter, with attention to detail.
• Experience in Design of Experiment approach and high-throughput protein purification platform will be valued.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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