Staff Scientist - Cutaneous Lymphoma

Join the forefront of groundbreaking research at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Staff Scientist position is available immediately in the laboratory of Dr. Christiane Querfeld, M.D., Ph.D. at Beckman Research Institute of City of Hope.

Christiane Querfeld, M.D., Ph.D., director of the Cutaneous Lymphoma program, seeks better treatment options for cutaneous T cell lymphoma (CTCL), a rare form of lymphoma that first appears on the skin but can also spread to lymph nodes and internal organs. City of Hope is one of the few institutions in the country that offers clinical trials to treat cutaneous lymphomas. Dr. Querfeld leads a multidisciplinary team of experts, including medical and radiation oncologists, pioneering treatments for CTCL and its subtypes.

Dr. Querfeld's laboratory investigations are focused on the tumor microenvironment in CTCL funded by national grants. She has demonstrated that cancer growth is fostered by the surrounding nonmalignant cells. These observations have led to the initiation of several targeted and immunologic therapies to restore the immune system and hereby killing the cancerous cells. Examples include an anti-CD47 construct enhancing macrophage killing and a randomized investigator-initiated trial comparing the checkpoint inhibitor anti-PD-L1 with/without the immunomodulatory drug lenalidomide. Her fundamental laboratory research activities involve dissecting key signaling pathways to advance therapeutic immunologic strategies including mechanisms of resistance.

As a successful candidate, you will:

• Under minimal direction of the Principal Investigator, direct the work of a laboratory including supervision of technical lab staff and is responsible for the development and execution of major research projects and performs state-of-the-art, complex research projects in collaboration with the other researchers, making significant, original contributions to research methods, including authorship or co-authorship of published findings.

• Ensure that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material. Plan and direct the work of research associates, lab assistants, technicians and aides.

• Train laboratory staff in specialized procedures, methodologies and equipment use and maintenance. Keep abreast of new and improved methodologies and technologies.

• Contribute original ideas of methodological significance to the laboratory, standardize new techniques and trains laboratory staff in their use. Perform specialized procedures and prepare written reports of laboratory methods.

• Independently evaluate research data and initiate alternative approaches to improve the quality of results by providing input to overall research design that maximizes samples or refines the use of specialized techniques. Troubleshoot procedures if experiment results are unexpected or unsatisfactory.

• Participate in the preparation of research grants, manuscripts and presentations.

Your qualifications should include:

• Ph.D. degree in a relevant field with at least 3 years of experience as a postdoc.

• Experience with mouse (PDX, humanized) models.

• Ability to effectively lead other scientists in a translational research environment in order to successfully meet deadlines and perform and prioritize simultaneous tasks.

• Requires use of discretion and judgment when handling confidential information.

• Ability to design and execute experiments, critically interpret experimental results, and present data in a cogent and meaningful manner.

• Industrious performance, sound technical skills and capable drafting grant proposals, research protocols and manuscripts.

Preferred qualifications:

• Possess expertise in handling high-dimensional analysis of primary tissues, including multi parameter flow cytometry, multiplex analysis, gene expression profiling, integration of single cell and spatial transcriptomics, and exosome analysis.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

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